USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers ...

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are ...

The two AFC West squads will face off in the desert on Sunday afternoon. After six weeks of dealing with turf toe, San Francisco 49ers quarterback Brock Purdy will be back in action on Sunday, Nov.

Now the San Francisco 49ers look like a team that might be peaking at the right time. Purdy threw three touchdown passes, Christian McCaffrey had two rushing touchdowns and a receiving score, and the ...

Brock Purdy completed 19 of 26 pass attempts for 200 yards and three touchdowns, earning a 133.5 passer rating. His 61.9 offensive grade (61.6 passing grade) ranked ninth among 49ers offensive ...

A former NFL star accused the Arizona Cardinals of point-shaving against the 49ers on Sunday after San Francisco cruised to a 41-22 victory in the NFC West showdown. LeSean McCoy is one of two ...

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the ...

On Sunday, Brock Purdy and Ricky Pearsall returned to the offensive lineup for the San Francisco 49ers. Purdy looked like he hadn't missed any time at all, as the offense dominated. The defense wasn ...

Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly two years. While Purdy looked sharp in the 41-22 victory over the Arizona Cardinals on Sunday, the ...

Tennessee lost 37-24 to the San Francisco 49ers on Dec. 14 at Levi's Stadium, with the 49ers scoring on their first five ...