You've seen the model's best bets for New York Giants vs. San Francisco 49ers. Now, get against the spread, total and money-line picks for every Week 9 NFL game here, all from the model that's simulated every game 10,000 times.

Can the 49ers' defense overcome injuries and a surging Rams offense? Keys to securing another victory and sweeping their division rival.

For the 49ers, Ricky Pearsall remained a non-participant, missing practice once again. Brock Purdy was limited for the second straight day and is uncertain to play against the Rams, while Dee Winters was downgraded from limited to DNP.

Sunday, in the media room at MetLife Stadium, where the New York Jets, the New York Giants and NFL players’ ACLs go to die each week, San Francisco 49ers head coach Kyle Shanahan subtly gave the most revealing update on quarterback Brock Purdy’s lingering toe injury.

The Rams and 49ers rewrite a new chapter into their famed rivalry on Sunday. Here's where the Rams have the edge.

The San Francisco 49ers got back to winning ways on Sunday, and it was thanks in large part to another strong performance from star running back Christian McCaffrey. The Niners were on the road at MetLife Stadium for Week 9. They took down the New York Giants, 34-24, to improve to 6-3 on the season.

The 49ers have yet to open the practice window for Brandon Aiyuk to return, which should start to set in a harsh reality.

J.B. Long, D'Marco Farr, and Maurice Jones-Drew sit down on the newest episode of Between The Horns to discuss the Los Angeles Rams' newly signed players on special teams and predictions ahead of Sunday's matchup against the San Francisco 49ers.

A storied rivalry will add another significant chapter Sunday afternoon when the San Francisco 49ers stare down the Los Angeles Rams at Santa Clara, Calif.

San Francisco 49ers QB Mac Jones got effective protection to beat the Giants, but credit some of that success to Kyle Shanahan's plan for how to keep New York's vaunted pass rush from being a factor.