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San Francisco 49ers vs. Indianapolis Colts recap today

Brock Purdy, 49ers Make History as NFL Fans Hype Battle vs. Philip Rivers, Colts

Brock Purdy and the San Francisco 49ers earned a statement 48–27 road win over Philip Rivers and the Indianapolis Colts on Monday Night Football, as both quarterbacks put on an entertaining aerial sho...

· 13m · on MSN

Brock Purdy throws 5 touchdowns, spoils Philip Rivers' return to Indianapolis in 49ers' win over Colts

Bucs Wire · 1h

San Francisco 49ers vs Indianapolis Colts recap today: Purdy's huge night buries Colts

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How to watch 49ers vs. Colts: TV channel, streaming, odds

The San Francisco 49ers (10-4) will try to extend a four-game winning streak when they visit the Indianapolis Colts (8-6) on Monday, December 22, 2025 at Lucas Oil Stadium.

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49ers thrash Colts behind Purdy’s 5 TD passes: Live updates and reaction from NFL ‘Monday Night Football’

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What channel is Monday Night Football on? How to watch 49ers vs Colts

· 20h

Monday Night Football predictions, picks, odds for Colts vs 49ers game

The Arizona Republic is predicting a 20-17 win for the 49ers over the Colts in the NFL Week 16 Monday Night Football game.

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San Francisco 49ers at Indianapolis Colts best prop bets for Monday Night Football

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Winners and losers as 49ers outlast Philip Rivers, Colts 48-27 on Monday night

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· 39m

3 players to blame for Colts MNF loss to 49ers

The Indianapolis Colts endured a stunning smackdown on Monday Night Football in Week 16.

· 7h · on MSN

4 takeaways from the 49ers' win over the Colts

USA TODAY Touchdown Wire on MSN · 1d

4 Colts players out v. 49ers; one key offensive player questionable

· 7h

Brock Purdy's career-high five TD passes power 49ers past Philip Rivers' Colts on 'Monday Night Football'

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game.

· 14h

What are the Indianapolis Colts playoff chances?

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49ers fans thinking Super Bowl after commanding MNF win over Colts

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Colts lose fifth straight to 49ers on MNF as playoff hopes hang by a thread

49ers quarterback Brock Purdy threw for 295 yards and five touchdowns, spreading the ball to seven different receivers while repeatedly exploiting mismatches over the middle.

· 7h

49ers offense can’t be stopped in 48-27 win over Colts

· 7h

49ers top Colts, 48-27, on Monday Night Football | Live Game Blog

21mon MSN

Chargers officially in playoffs after 49ers pull away to beat fading Colts

Brock Purdy throws a career-high five touchdown passes and Dee Winters returns an interception 74 yards for a TD in a 48-27 win in Indianapolis. The Colts’ loss clinches playoff spots for the

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49ers' Brock Purdy resembles vintage Phillip Rivers in outdueling legend: ‘Close to perfect'

Brock Purdy continued to show little respect for his elders as the San Francisco 49ers beat Philip Rivers and the Colts, spoiling the show for a national audience.

Niners Wire on MSN

49ers vs. Colts highlights: SF extends win streak to 5 games

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

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What 49ers' Brandon Aiyuk Situation Could Mean for Rams

WOODLAND HILLS, Ca. While the Los Angeles Rams have dealt with their own issues, spurred on by Puka Nacua's recent appearance on a livestream with Adin Ross and

Purdy leads 49ers with 5 TD throws

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers' final pass 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory over the Indianapolis Colts on Monday night.

What Kyle Shanahan told 49ers in team meeting after clinching NFL playoff spot

San Francisco coach Kyle Shanahan revealed what he told the 49ers in a team meeting after clinching a spot in the 2025 NFL playoffs on Sunday night.

17hon MSN

Key starters expected to return for San Francisco 49ers in Week 16

The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never get completely healthy, it is signif