Also in the mix is top 10 pound-for-pound fighter Jesse "Bam" Rodriguez in a unification bout with Phumelela Cafu at junior bantamweight. WBC champ Rodriguez has emerged as one of the best fighters in the world at just 24 years old and is looking to add another belt to his collection when he faces WBO champion Cafu.

In his last outing, in 2021, Pacquiao looked slow and overmatched against Yordenis Ugas. Pacquiao lost a unanimous decision and was outlanded by Ugas in total punches (151-130), jabs (50-42) and power punches (101-88).

The weekend is packed with Pacquiao vs. Barrios and Usyk vs. Dubois on the card. Here are picks for the biggest fights.